The Congregation of the Blessed Sacrament began working with children in Paris to prepare them to receive their First Communion. It also reached out to non-practicing Catholics, inviting them to repent and begin receiving Communion again. Eymard was a tireless proponent of frequent Holy Communion, an idea given more authoritative backing by Pope Pius X in 1905.
Eymard overcame a number of difficulties to reach his goals, including poverty in his family and in his newly founded community, his father's initial opposition to his only son’s desire to be a priest, years of serious illness and pain, a Jansenistic striving for inner perfection and the difficulties of getting diocesan and later papal approval for his new religious community. Eymard was a contemporary and a friend of other saints including Peter Chanel, John Vianney and Marcellin Champagnat.
The French sculptor Auguste Rodin received counsel from Eymard when Rodin entered the Congregation as a lay brother in 1862, having given up art after the death of his sister. Eymard recognized Rodin's talent and advised him to return to his vocation. Rodin later produced a bust of Eymard.
Eymard died on 1 August 1868. He was declared venerable in 1908, beatified in 1925, and canonized by Pope John XXIII on 9 December 1962. His feast day is celebrated in the Roman Catholic Church on 2 August. He was named Apostle of the Eucharist.